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Doctors usually diagnose iron overload with these blood tests: serum ferritin : measures the. We suppose that this protective role is due to atrophic body gastritis with iron malabsorption. It seems that pernicious anaemia may prevent manifestations of hemochromatosis. We report a case of paradoxical association of hereditary hemochromatosis and pernicious anaemia. The association between pernicious anaemia and hereditary hemochromatosis has never been described. It is characterized by increased absorption of dietary iron. Hereditary hemochromatosis is inherited as an autosomal recessive trait. dollars per annum) associated with the management of this disease. Early diagnosis and treatment will reduce the population of aging individuals with severe, complicated hemochromatosis and dramatically reduce medical costs (billions of U.S. Screening, identification and early treatment (phlebotomies, sometimes in combination with the use of Desferal or other iron-chelating agents) may help prevent or reduce iron-related organ damage and premature deaths. Family members of hereditary hemochromatosis patients are at increased risk and should be tested. Population screening should include measurements of serum iron concentration, total iron binding capacity (TIBC), percent saturation of transferrin, and serum ferritin concentrations. Patients at risk for genetic hemochromatosis should be screened, identified, and treated as early as age 20 to prevent or minimize the deadly complications of hemochromatosis. Iron overload owing to HLA-linked hereditary hemochromatosis can be distinguished from other causes of hemochromatosis by liver biopsies and interpretations. Early diagnosis can prevent these excess iron-induced problems. Excess iron storage eventually produces pituitary, pancreatic, cardiac, and liver dysfunction and death may result from cardiac arrhythmias, congestive heart failure, and/or hepatic failure or cancer.

Hereditary hemochromatosis involves an increased rate of iron absorption from the gut with subsequent progressive storage of iron in soft organs of the body. Homozygous individuals may develop severe and potentially lethal hemochromatosis, especially after age 39.

The hemochromatosis gene is probably located close to the HLA-A locus on the short arm of chromosome 6. Genetic ( hereditary) hemochromatosis is probably the most common autosomal recessive disorder found in white Americans, of whom about 5/1,000 (0.5 percent) are homozygous for the associated gene. Walker, E M Wolfe, M D Norton, M L Walker, S M Jones, M M

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